VU0360172 hydrochloride is a selective, orally active mGluR5 PAM with an EC50 value of 16 nM and a Ki value of 195 nM. VU0360172 hydrochloride produced a dose-dependent reversal of amphetamine-induced hyperlocomotion, a rodent model predictive of antipsychotic activity.
KEYWORDS: VU0360172 hydrochloride | Supplier | mGluR5 PAM | VU 0360172 hydrochloride | VU-0360172 hydrochloride | CAS [1309976-62-2] | [1310012-12-4] | Glutamate | mGluR5 | PAM | Receptors | Anxiety | Schizophrenia
| CAS Number | 1309976-62-2 |
| Molecular Formula | C18H15FN2O.HCl |
| Purity | ≥95% |
| IUPAC Name | N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]pyridine-3-carboxamide;hydrochloride |
| InChI | InChI=1S/C18H15FN2O.ClH/c19-15-4-1-3-13(11-15)7-9-16-10-8-14(12-20-16)18(22)21-17-5-2-6-17;/h1,3-4,8,10-12,17H,2,5-6H2,(H,21,22);1H |
| SMILES | C1CC(C1)NC(=O)C2=CN=C(C=C2)C#CC3=CC(=CC=C3)F.Cl |
| Reference | AL Rodriguez et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. |
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