Lithium tert-Butoxide(CAT: R033461) is a mild base used in organic synthesis experiments. It can catalyze nucleophilic substitution reactions, such as the preparation of n-alkylation products, and can catalyze reduction reactions, such as the reduction of ketones to alcohols. This product is used in organic synthesis and other scientific research fields.
| CAS Number | 1907-33-1 |
| Synonyms | 2-Methyl-2-propanol Lithium Salt; Lithium t-butoxide; Lithium tert-Butanolate;?Lithium tert-Butylate; tert-Butanol Lithium Salt; tert-Butoxylithium; |
| Molecular Formula | C4H9LiO |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | lithium;2-methylpropan-2-olate |
| InChI | InChI=1S/C4H9O.Li/c1-4(2,3)5;/h1-3H3;/q-1;+1 |
| InChIKey | LZWQNOHZMQIFBX-UHFFFAOYSA-N |
| SMILES | [Li+].CC(C)(C)[O-] |
| Reference | <p style=”box-sizing: border-box; margin: 0px 0px 10px; color: rgb(118, 118, 118); font-family: Roboto, "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; font-variant-ligatures: normal; orphans: 2; widows: 2;”> <span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-variant-ligatures: normal;”>1.Liang, Yu-Feng, et al. "Lithium tert-butoxide mediated α-alkylation of ketones with primary alcohols under transition-metal-free conditions." </span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal;”>RSC advances</i><span style=”font-variant-ligatures: normal;”> 3.21 (2013): 7739-7742.</span><br /> 2.Lee, C. W.; Han, S. J.; Virgil, S. C.; Stoltz, B. M. Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with alpha-arylated malonate esters. <em style=”box-sizing: border-box;”>Tetrahedron </em>2015,<em style=”box-sizing: border-box;”>71</em> (22), 3666-3670.</span></span></span><span style=”font-family: arial, helvetica, sans-serif; font-size: 12px; color: rgb(0, 0, 0);”>3.Lou, S.; Ramirez, A.; Conlon, D. A. Catalytic syn-Selective Direct Aldol Reactions of Benzophenone Glycine Imine with Aromatic, Heteroaromatic and Aliphatic Aldehydes. </span><em style=”font-family: arial, helvetica, sans-serif; font-size: 12px; color: rgb(0, 0, 0); box-sizing: border-box;”>Adv. Synth. Catal.</em><span style=”font-family: arial, helvetica, sans-serif; font-size: 12px; color: rgb(0, 0, 0);”> </span><span style=”font-family: arial, helvetica, sans-serif; font-size: 12px; color: rgb(0, 0, 0);”>2015, </span><em style=”font-family: arial, helvetica, sans-serif; font-size: 12px; color: rgb(0, 0, 0); box-sizing: border-box;”>357</em><span style=”font-family: arial, helvetica, sans-serif; font-size: 12px; color: rgb(0, 0, 0);”> (1), 28-34.</span></p> |
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